Medical Device Exits
Advanced Cardiac Therapeutics
AFIB ablation
Device - Sucessful Exit
Acquired by Medtronics (MDT) in 2019
Advanced Cardiac Therapeutic’s technology does Radio-frequency (RF) ablation for Atrial Fibrillation (AFIB) - irregular heartbeat. The device accurately monitors temperature during ablation so a skilled operator can use the feedback to reduce ablation times by over 50%. Applications extend to other arrhythmias.
CV Ingenuity
Vascular balloon
Device - Sucessful Exit
Acquired by Covidien (COV) in 2012
CV Ingenuity uses an off-the-shelf balloon coated with drugs for the "Touch-and-Go" treatment of vascular disease. Uses include relieve vascular obstructions, inhibit restenosis (vessel narrowing), and allow natural vessel healing. Company focused on domestic market and the superficial femoral artery (SFA) market. The SFA is a long artery through the thigh with few side branches.
Device - Sucessful Exit
Acquired by Kinetic Concepts (KCI) in 2012
Momelan Technologies
Skin grafting
MoMelan offers an autologous (self-donor) skin grafting solution utilizing site-sparing technology for enabling and standardizing the use of epidermal ("thin") skin grafting. It can be performed in the office or outpatient setting with minimal discomfort.
N Spine
Lumbar spine fusion
Device - Sucessful Exit
Acquired by Synthes (SYST) in 2007, now part of Johnson & Johnson (JNJ)
N Spine has devices for posterior fusion and dynamic stabilization of the lumbar spine via minimally invasive surgery. NFlex is a titanium pedicle screw system with a novel design that provides dynamic support to the spinal motion segment.
Nanostim
Leadless pacemaker
Device - Successful Exit
Acquired by St. Jude Medical in 2013, now part of Abbott (ABT)
Nanostim created the world’s first commercially available, self-contained leadless implantable pacemaker. The pacemaker can be inserted by catheter into the heart and is self-contained with battery so there are no external leads. Major heart surgery is avoided.
N Vision
Ovarian cancer diagnosis
Device - Successful Exit
Acquired by Boston Scientific (BSX) in 2017
N Vison produced an FDA-cleared device that collects cells from fallopian tubes for an early diagnosis of ovarian cancer. This diagnosis plays an important role in early detection of the disease and the prevention of unnecessary surgeries.
Textronics
Wearable fitness monitor
Device - Successful Exit
Acquired by Addidas (ADDYY)
Textronics pioneered wearable fitness monitoring. It integrates sensing fibers directly into the fabric of garments, allowing for the measurement of electrical, optical or magnetic signals. Prior technologies used cumbersome electrodes attached to the body.
Vasonova
Vascular navigation
Device - Successful Exit
Acquired by Teleflex (TFX) in 2011
Vasonova was first company to use a unique micro-Doppler ultrasound technology in combination with intravascular ECG to provide precise guidance for nurses and technicians to enable correct navigation and placement of catheter tips.
Medical Device - Selected Recent Investments
Abterra Bio
Antibody Identification
abterrabio.com
Device - Recent
Invested 2021
Abterra Biosciences uses next-generation sequencing, mass spectrometry, and bioinformatics to identify antibody proteins from the serum of disease survivors to identify the best drug candidates.
AmplifiDx
Molecular POC
amplifiDx.com
Device - Recent
Invested 2021
AmplfiDx is the next generation molecular point-of-care platform. Their swab-to-answer cartridge-based system is sensitive, multiplexed, easy to use, and designed for low-cost, robust manufacturing. The platform is positioned to take advantage of the “out of the clinic into the world” post-COVID market.
Avisi
Technologies
Nanotech
Glaucoma Implant
avisitech.com
Device - Recent
Invested 2020
Avisi’s nanotechnology-enabled ocular implant treats glaucoma, the leading cause of irreversible blindness that affects ~100M people. The VisiPlate is an ultrathin, multichannel, non-fibrotic implant that preserves vision by lowering eye pressure in patients. VisiPlate leverages a novel shape-recovering, plate metamaterial to achieve greater safety and sustained efficacy compared to current solutions.
Basilard
Nanomechanical Transfection
Basilard
Device - Recent
Invested 2022
Basilard delivers genes to cell nuclei ex-vivo in a manner that scales. Its nano sized mechanoporation technology uses fluid flow to drag each cell in suspension into its own well in a large site capture array where the plasma and nuclear membranes are then precisely porated by a dedicated needle.
Celldom
Single Cell Analysis
celldom.com
Device - Recent
Invested 2021
Celldom's instrument, consumables, and software analyze single cells in a massively parallel format. Its image-based phenotyping and high resolution transcriptional and genomic analysis of single cells at an affordable price serves academic and industrial markets for drug development and precision medicine.
Embolyx
Embolize tumors
embolx.com
Device - Recent
Invested 2016, 2017, 2019
Embolx has developed a micro-catheter (“SNIPER”) for embolization of solid tumors. SNIPER delivers record precision in delivery of embolization media to the tumors, embolization and reduces non-target parasitic embolization flow into neighboring organs that reduces clinical complications. Initial applications to liver cancer.
Fluxion
Liquid Biopsies
fluxionbio.com
Device - Recent
Invested 2016, 2018
Fluxion has 3 commercial platforms: IsoFlux – a liquid biopsy platform, Ion Flux - a high throughput screening platform for ion channel drug discovery, and BioFlux – a microfluidic platform for studying cell-cell interactions in physiological state.
iDentical
Tooth Implant - no drill
iDenticalimplant
Device - Recent
Invested 2020
iDentical is leveraging the latest 3D technology to develop a drill-free dental implant. It's non-invasive, faster and more affordable than dental implants today. Within a week of tooth extraction, a dentist can insert the iDentical implant into the existing socket.
Life Detection Technologies
At-home monitoring
LDT
Device - Recent
Invested 2021
Life Detection Technologies has built a novel vital sign monitor which combines the accuracy of today's best medical equipment with the ease of never having to wear, or do, anything. The level of accuracy, combined with near 100% compliance, offered by our device opens up many new opportunities in the care of individuals outside of hospitals.
Nervonik
Neuro-modulation
nervonik.com
Device - Recent
Invested 2021
Nervonik is a stealth-mode startup company that has developed a novel and miniaturized neuromodulation device for therapeutic applications.
Neurava
Epilepsy Warning
neurava.com
Device - Recent
Invested 2022
Neurava is developing novel, AI-powered wearables for epilepsy patients to mitigate the risk of Sudden Unexpected Death in Epilepsy (SUDEP), which causes 101,000 years of potential life lost, second only to stroke amongst all neurological disorders.
Noctrix
Restless Leg Syndrome
noctrixhealth
Device - Recent
Invested 2018, 2020
Noctrix Health is addressing symptoms of Restless Legs Syndrome with a wearable neuromodulation platform technology. Noctrix targets specific peripheral nerve fibers in the legs with a proprietary waveform that maximizes sensory activation while minimizing muscle recruitment and stimulus perception, making it comfortable to wear to sleep.
Pelvital
Urinary Incontinence
pelvital
Device - Recent
Invested 2024
Pelvital's FDA-cleared Flyte device uses novel technology to deliver mechanotherapy transvaginally to the pelvic floor to treat urinary incontinence. Backed by two published clinical trials, Flyte delivers outcomes comparable to surgery in a first-line, conservative, in-home treatment.
Renata
Adjustable stent
renatamedical.com
Device - Recent
Invested 2022
Renata has developed an adjustable stent for pediatrics that expands as the child grows and may last a lifetime. The stent is inserted in the patient at birth and the device’s ability to be re-expanded may eliminate the need for further surgeries. The device’s initial size is less than 2 millimeters in diameter and can expand to adult vessel sizes as the patient grows.
TheraDep
Biomolecule bonding theradep.com
Device - Recent
Invested 2018
TheraDep's cold plasma deposition technology bonds bio molecules or drugs to any surface, in a single step, without linkers or binders. TheraDep projects an aerosol of biologics through a cold plasma cloud of electrically charged gas to achieve covalent bonding of thin, conformal layers. First applications are for dermatology and for coatings on devices.
Valfix
Mitral valve leak fix
valfixmed.com
Device - Recent
Invested: 2019, 2020
Valfix has the first transcatheter solution that combines repair and replacement for Mitral or Tricuspid valve in one procedure. A transcatheter solution is one performed in the lumne (interior space) of a catheter. Valfix performs a non-surgical implantation of a ring to treat a leaking mitral valve for heart failure patients.